September 2010

Adrenal Exhaustion happens when the adrenal glands are unable to effectively secrete enough cortisol. (click here for my article on cortisol 101) There are three stages of adrenal fatigue (or exhaustion).

Stage 1 Adrenal Exhaustion is distinguished by an increase in output of ACTH by the anterior pituitary gland, increased adrenocortical stimulation, increased cortisol output and an increased probability of pregnenolone steal and decreased DHEA.  Each stage is progressively associated with reduced cortisol production and increased adrenaline. (1)

Stage II Adrenal Exhaustion is marked by the transition from increased to decreased cortisol output. This stage is characterized by continuing high levels of ACTH and thus: adrenocortical stimulation, normal total cortisol output, low or borderline low morning, noon or afternoon cortisol levels, normal nighttime cortisol level, and an increased probability of pregnenolone steal and a further decrease in DHEA. This is a transitional phase in which although ACTH stimulation remains high or even increases, the adrenal output of cortisol declines due to the adrenal fatigue associated with continued hyper stimulation. (1)

Stage III Adrenal Exhaustion is an advanced stage of adrenal exhaustion characterized by decreased total cortisol output. This stage is characterized by continuing high levels of ACTH and thus adrenocortical stimulation, low total cortisol output, and increased probability of a low nighttime cortisol level and pregnenolone steal and even further decrease in DHEA. The adrenal glands are now exhausted to the point that even though there is ongoing hyperstimulation (high ACTH); they continue to lose their capacity and reserve to produce enough cortisol. The eventual result is a crash of the hypothalamic-pituitary-adrenal axis (HPAA) in which essential neuroendocrine feedback loops are unable to return the system to homeostasis.(1)

What is the Cause of Adrenal Exhaustion?

1. Prolonged periods of stress:

Multiple stressors happening at the same time, such as financial problems, emotional issues, environmental concerns, cultural difficulties, poor eating habits, too many stimulants, overworking, inadequate sleep – to name a few.

2. A traumatic event or acute stressor

3. A combination of both acute and non-acute stressors

Many Common Symptoms of Adrenal Exhaustion are similar to those of depression. [click to continue…]

{ 4 comments }