
If your urine smells after eating asparagus, you have the MTHFR (methylenetetrahydrofolate reductase) gene. This gene inhibits optimal function of the body’s folate system – increasing your risk of heart disease.
Which populations are at higher risk for carrying the MTHFR gene?
A large majority of the research behind the MTHFR gene has been done on American and French populations. Notably, only about 2% of the French have this gene, while an estimated 40-50% of the Americans have it. The lack of the MTHFR gene in the French population contributes to the well known French Paradox theory. Further cross cultural studies need to be done. However, if you are reading this, simply have an asparagus feast, drink lots of water after your meal and have fun with your experiment.
Common asparagus experiment question: Some people say to me, “I don’t know if my urine really smells.” I simply tell them, “either you have a severe sinus infection or you don’t have the gene.” I might add that you do not need to put your head in the bowl to accurately conclude the results.
The MTHFR gene can raise homocysteine levels, increasing the risk of heart disease. What can you do about it?
A high homocysteine level is a known risk factor for developing cardiovascular disease. If you have a family history of heart disease, it is especially important to monitor your homocysteine (tHcy) level. I recommend that you include tHcy in your annual blood panel as part of your preventive health program. Using lab tests as a preventive health measure is absolutely critical to preventing heart disease. Even if your homocysteine level is within the normal range, you’ll want to know if it is increasing over time. If you find your level is slowly rising, take action while it is sub-clinical!
There are many lifestyle, diet and exercise changes you can make to keep your level from rising. However, this article will focus in on a simple supplemental step you can take to prevent your tHcy level from rising (with the assumption you have MTHFR gene).
Oral Supplementation of L-5 MTHF (Methyltetrahydrofolate) is Superior over Folic Acid:
It might interest you to know that “Merck successfully synthesized folic acid into a stable and substantially pure form of L-methylfolate – the body’s preferred form of folate –which is able to cross the blood-brain barrier without further bioconversion by the body. MERK markets this unique form of L-methylfolate under the trade name Metafolin®. Metafolin® is not folic acid, but rather it is a distinct dietary ingredient achieved through a unique and innovative method that yields L-methylfolate in a stable and substantially pure form.” (Case 2:10-cv-04365-MVL-DEK Document 1)
About 7 years ago, a medical supplement company (Metagenics) had exclusive rights for a couple of years on a specific therapeutic dosage of 1000mg capsules. Their exclusive rights have since expired and it is now an open market for L-5 methyltetrahydrafolate supplements.
Oral supplementation of L-5 MTHF is one step towards reducing or maintaining your lab scores. Several studies comparing supplemental L-5 MTHF versus folic acid prove the L-5 form to be more successful at lowering homocysteine levels. Straight folic acid may help tHcyscores but it can mask B-12 deficiency on a lab test, making L-5 MTHF (methyltetrahydrofolate) supplementation a superior choice. If you currently take supplemental folic acid and you feel fatigued, please note that it may be due to a B-12 deficiency which the lab isn’t picking up because you are not on the L-5 form. This is a problem, because if your doctor is unaware of the folic acid masking effect, you may end up wasting time on other tests that may be contributing to your fatigue. Vitamin B-12 deficiency is one of the most common deficiencies in the U.S., especially among the elderly and those who have the MTHFR (methylenetetrahydrofolate reductase) gene.
If you have the gene, you will want to take a multi-vitamin containing L-5 in it or take it as an add on nutracutical.
I highly recommend the Multi Intense Iron Free vitamin from Charles Poliquin which contains L-5. If you are content with your multivitamin, you can take L-5 separately by ordering Methylator Plus 3.0.
Those of you who do not have the MTHFR gene need not take L-5 form, because your folate system is functioning properly, giving you enough B-12 and keeping your homocysteine levels low.
If you are a client of ours, you have access to the full Metagenics line as well as Charles Poliquins tarteted supplements used alongside our BioSignatrue Program.
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A large majority of the research behind the MTHFR gene has been done on American and French populations. Notably, only about 2% of the French have this gene, while an estimated 40-50% of the Americans have it. The lack of the MTHFR gene in the French population contributes to the well known French Paradox theory. Further cross cultural studies need to be done. However, if you are reading this, simply have an asparagus feast, drink lots of water after your meal and have fun with your experiment.
Common asparagus experiment question: Some people say to me, “I don’t know if my urine really smells.” I simply tell them, “either you have a severe sinus infection or you don’t have the gene.” I might add that you do not need to put your head in the bowl to accurately conclude the results.
The MTHFR gene can raise homocysteine levels, increasing the risk of heart disease. What can you do about it?
A high homocysteine level is a known risk factor for developing cardiovascular disease. If you have a family history of heart disease, it is especially important to monitor your homocysteine (tHcy) level. I recommend that you include tHcy in your annual blood panel as part of your preventive health program. Using lab tests as a preventive health measure is absolutely critical to preventing heart disease. Even if your homocysteine level is within the normal range, you’ll want to know if it is increasing over time. If you find your level is slowly rising, take action while it is sub-clinical!
There are many lifestyle, diet and exercise changes you can make to keep your level from rising. However, this article will focus in on a simple supplemental step you can take to prevent your tHcy level from rising (with the assumption you have MTHFR gene).
Oral Supplementation of L-5 MTHF (Methyltetrahydrofolate) is Superior over Folic Acid:
It might interest you to know that “Merck successfully synthesized folic acid into a stable and substantially pure form of L-methylfolate – the body’s preferred form of folate –which is able to cross the blood-brain barrier without further bioconversion by the body. MERK markets this unique form of L-methylfolate under the trade name Metafolin®. Metafolin® is not folic acid, but rather it is a distinct dietary ingredient achieved through a unique and innovative method that yields L-methylfolate in a stable and substantially pure form.” (Case 2:10-cv-04365-MVL-DEK Document 1)
Is the material in quotation marks a direct quote from Merk?
About 7 years ago, a medical supplement company (Metagenics) had exclusive rights for a couple of years on a specific therapeutic dosage of 1000mg capsules. Their exclusive rights have since expired and it is now an open market for L-5 methyltetrahydrafolate supplements.
Oral supplementation of L-5 MTHF is one step towards reducing or maintaining your lab scores. Several studies comparing supplemental L-5 MTHF versus folic acid prove the L-5 form to be more successful at lowering homocysteine levels. Straight folic acid may help tHcyscores but it can mask B-12 deficiency on a lab test, making L-5 MTHF (methyltetrahydrofolate) supplementation a superior choice. If you currently take supplemental folic acid and you feel fatigued, please note that it may be due to a B-12 deficiency which the lab isn’t picking up because you are not on the L-5 form. This is a problem, because if your doctor is unaware of the folic acid masking effect, you may end up wasting time on other tests that may be contributing to your fatigue. Vitamin B-12 deficiency is one of the most common deficiencies in the U.S., especially among the elderly and those who have the MTHFR (methylenetetrahydrofolate reductase) gene.